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Results of annual screening in phase I of the United Kingdom familial ovarian cancer screening study highlight the need for strict adherence to screening schedule

机译：英国家族性卵巢癌筛查研究的第一阶段年度筛查结果强调了严格遵守筛查时间表的必要性

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Purpose: To establish the performance characteristics of annual transvaginal ultrasound and serum CA125 screening for women at high risk of ovarian/fallopian tube cancer (OC/FTC) and to investigate the impact of delayed screening interval and surgical intervention. Patients and Methods: Between May 6, 2002, and January 5, 2008, 3,563 women at an estimated ≥ 10% lifetime risk of OC/FTC were recruited and screened by 37 centers in the United Kingdom. Participants were observed prospectively by centers, questionnaire, and national cancer registries. Results: Sensitivity for detection of incident OC/FTC at 1 year after last annual screen was 81.3% (95% CI, 54.3% to 96.0%) if occult cancers were classified as false negatives and 87.5% (95% CI, 61.7% to 98.5%) if they were classified as true positives. Positive and negative predictive values of incident screening were 25.5% (95% CI, 14.3 to 40.0) and 99.9% (95% CI, 99.8 to 100) respectively. Four (30.8%) of 13 incident screen-detected OC/FTCs were stage I or II. Compared with women screened in the year before diagnosis, those not screened in the year before diagnosis were more likely to have ≥ stage IIIc disease (85.7% v 26.1%; P = .009). Screening interval was delayed by a median of 88 days before detection of incident OC/FTC. Median interval from detection screen to surgical intervention was 79 days in prevalent and incident OC/FTC. Conclusion: These results in the high-risk population highlight the need for strict adherence to screening schedule. Screening more frequently than annually with prompt surgical intervention seems to offer a better chance of early-stage detection. © 2012 by American Society of Clinical Oncology.
机译：目的：建立年度经阴道超声检查和血清CA125筛查对卵巢癌/输卵管癌（OC / FTC）高风险女性的性能特点，并探讨延迟筛查间隔和手术干预的影响。患者和方法：在2002年5月6日至2008年1月5日之间，英国37个中心招募了3,563名女性，估计她们的OC / FTC终生风险≥10％。通过中心，问卷调查和国家癌症登记系统对参与者进行了前瞻性观察。结果：如果隐匿性癌症被归类为假阴性，则在上次年度筛查后第1年检测到OC / FTC事件的敏感性为81.3％（95％CI，54.3％至96.0％）和87.5％（95％CI，61.7％至95％CI）。 98.5％），如果它们被分类为真阳性。事故筛查的阳性和阴性预测值分别为25.5％（95％CI，14.3至40.0）和99.9％（95％CI，99.8至100）。在第一阶段或第二阶段，有13个事件通过屏幕检测到的OC / FTC中有四个（30.8％）。与诊断前一年筛查的女性相比，诊断前一年未筛查的女性更有可能患有≥IIIc期疾病（85.7％v 26.1％； P = .009）。在检测到OC / FTC事件之前，筛查间隔被延迟了88天。 OC / FTC发生率和发病率从检测筛查到手术干预的中位间隔为79天。结论：高危人群的这些结果强调了严格遵守筛查时间表的必要性。与每年进行一次及时的外科手术干预相比，每年进行筛查的频率似乎更高，可以提供早期发现的更好机会。 ©2012，美国临床肿瘤学会。

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